16 Probiotic Strains That Reduce Inflammation

Did you know that there are many probiotic strains that reduce inflammation?

Inflammation is a necessary part of the body’s immune response but the wrong kind of inflammation can cause all sorts of health issues that have uncomfortable side effects.

Some inflammation is good and normal but when chronic inflammation sets in, it puts the body in a constant state of alert. Luckily, probiotics can help.

Below, you’ll learn more and inflammation and you’ll find the probiotic strains that reduce inflammation.


What is Inflammation?

Inflammation is the body’s immune response to foreign irritants that enter the body. Usually that means bacterial or viral pathogens that can cause infection but inflammation is also triggered by foreign objects, such as splinters.

Inflammation isn’t all bad. Inflammation protects the body from infection and helps heal injuries. However, inflammation that lasts for an extended period of time, known as chronic inflammation, can do more harm than good.

The prevalence of chronic intestinal diseases has been increasing in developed regions around the world over the past decades. (1) Researchers attribute this to the modern Western lifestyle and diet. (2)


Negative Effects of Inflammation

The negative effects and symptoms of inflammation range from minor inconveniences to conditions that can seriously affect your life.

Some of the more common symptoms of inflammation include:
  • Swelling
  • Pain
  • Redness
  • Feeling hot
  • Loss of movement or function of body parts

Some of the more serious symptoms of long-term, chronic inflammation include:
  • Weight gain
  • Body pain
  • Frequent infections
  • Fatigue
  • Trouble sleeping
  • Acid reflux
  • Diarrhea
  • Constipation
  • Mood disorders such as anxiety and depression 

Some of the most common symptoms that people with inflammatory bowel disease experience include:
  • Diarrhea
  • Weight loss
  • Cramping, bloating, stomach pain
  • Ulcers
  • Anemia

There are many other symptoms that inflammatory conditions can cause. In rheumatoid arthritis, for example, your joints are attacked by your own immune system, which can lead to symptoms such as joint pain, stiffness, swelling, tingling, numbness, and loss of motion in the joints.


Here are The Probiotic Strains that Reduce Inflammation:

Infographic of the best probiotic strains that reduce inflammation

1) Bacillus Coagulans

Bacillus coagulans is a probiotic bacteria that forms spores during its reproductive stage, which is a unique ability among probiotics. This means that it can go dormant while in harsh environments, such as in the stomach’s acid, making its survivability more robust than other probiotic strains.

In lab studies in animals and people, bacillus coagulans has “demonstrated anti-inflammatory and immune-modulating effects”. (3)


2) Bifidobacterium bifidum

Bifidobacterium strains are commonly included in probiotic products — and for good reason. Bifidobacteria are one of the most common strains found naturally in the human gut and have many health benefits, from improving digestion to increasing the metabolism, to strengthening the immune system. (4)

In a study with 16 human patients with ulcerative colitis (a disease caused by inflammation, A.K.A. IBD, or inflammatory bowel disease), a probiotic combination including bifidobacterium bifidum restored patients' mucosal barriers, which helps the body fight off pouchitis and prevent it from recurring. (5)

3) Bifidobacterium Longum

A study in mice that were given bifidobacterium longum found that it had a protective effect against colitis, a chronic digestive disease caused by inflammation of the colon. Researchers concluded that this was achieved through the "modulation of the gut microbiota". (6)

A study done in human patients with ulcerative colitis found that 63% saw clinical remission in their condition. (7) More research is needed.


4) Bifidobacterium breve

In in vitro studies of bifidobacterium breve, researchers found that a treatment of probiotic strains including bifidobacterium breve decreased pro-inflammatory cytokines and chemokines, which are signaling molecules that induce inflammation in the body. (8) (9) (10)

In studies in animals with the inflammatory bowel disease colitis, probiotics including bifidobacterium breve decreased the severity of symptoms of colitis. (11) (12)


5) Bifibacterium lactis

There have been several animal studies showing that after taking bifidobacterium lactis, symptoms of inflammatory bowel disease improved. (11) (12)

In a study done in people with inflammatory bowel disease and pouchitis, a probiotic combination including the strain bifidobacterium lactis strengthened the immune response against e. coli. (5) Researchers said the “mechanisms behind these effects are not fully understood”.


6) Bacillus subtilis

There have been a relatively small number of studies done on this probiotic strain and its effects on inflammation but one study found that bacillus subtilis improved gut inflammation and dysbiosis (an imbalance of the microbiome in the gut). (13)


7) Lactobacillus acidophilus

Lactobacillus strains are one of the most common probiotics, along with bifidobacteria. The name ‘lactobacillus’ comes from the fact that it produces lactic acid by producing an enzyme called lactase after breaking lactose, a sugar found in milk.

There is evidence that suggests that lactobacillus acidophilus lowers inflammation. A study in mice found that a probiotic treatment including this probiotic strain decreased the severity of colitis by lowering inflammation. (11) Another study found that it improved clinical symptoms of colitis in mice. (12)

In a study in human patients with pouchitis, a probiotic combination including lactobacillus acidophilus strengthened the immune system against pathogens by lowering inflammation. (14)


8) Lactobacillus bulgaricus

Lactobacillus bulgaricus is a probiotic strain that is commonly used to produce yogurt.

This study found that probiotics had a local anti-inflammatory effect by modulating the intestinal flora.


9) Lactobacillus casei

Lactobacillus may improve the gut immune response by lowering and regulating inflammation. (15)


10) Lactobacillus lactis

Based on several studies, lactobacillus lactis is an anti-inflammatory.

A study in mice found that it lowered intestinal inflammation and has protective effects. (16) It also had benefits in studies done in people with inflammatory bowel disease (ulcerative colitis). (5)


11) Lactobacillus paracasei

In in vitro (test tube) studies, a probiotic combination including lactobacillus paracasei lowered proinflammatory cytokines, which induce inflammation. (8) (9) (10)

In a study done in human patients with pouchitis, a probiotic combination including lactobacillus paracasei restored the mucosal barrier, which protects against infections like E. coli. (5)


12) Lactobacillus salivarius

In a study in patients with ulcerative colitis and pouchitis, a probiotic combination containing lactobacillus salivarius strengthened participants’ mucosal barriers, which strengthens the immune system against pathogens like E. coli and HRP. (5)


13) Saccharomyces boulardii

Saccharomyces boulardii has been studied extensively and has been shown to lower inflammation and can be beneficial for people with inflammatory bowel disease. Researchers believe that saccharomyces boulardii does this by inhibiting the production of proinflammatory cytokines, which are signaling molecules that activate inflammation in the body.


14) Lactobacillus rhamnosus

Lactobacillus rhamnosus may protect the intestines from cell damage by lowering inflammation. (18) It may strengthen the immune system in the intestines by regulating inflammation. (9)

In an in vitro (test tube) study, a probiotic combination including lactobacillus rhamnosus lowered pro-inflammatory cytokines and chemokines, which are messenger molecules that induce inflammation, sometimes unnecessarily. (10)

In a study of lactobacillus rhamnosus in people with inflammatory bowel disease, participants had stronger immune responses. (20)


15) Lactobacillus reuteri

There hasn’t been a lot of research done into this probiotic and inflammation, but there have been promising results. Initial research in rats had results indicating that lactobacillus reuteri reduced the severity of experimental inflammatory bowel disease. (14) More research is needed.


16) Lactobacillus plantarum

In an in vitro study, results indicated that lactobacillus plantarum improved epithelial barrier function by lowering inflammation. (20) The intestinal epithelial barrier function is the gut’s line of defense against pathogens that can cause infection in the body.

A study in mice found that a probiotic combination including lactobacillus plantarum lowered the severity of colitis by reducing inflammation. (11) Another study in mice (with the inflammatory bowel disease colitis) found that after given this probiotic, the mice had stronger intestinal barriers and that the probiotics they received promoted tissue repair. (12)

Similar findings were also seen in scientific studies in rats. (21) (22)

A 2013 study in humans with ulcerative colitis found that symptoms improved after taking a product containing lactobacillus plantarum. (23) Another study in humans found that patients with pouchitis had a stronger mucosal barrier to pathogens after taking this probiotic (i.e. their immune systems were strengthened). (5)

The Best Probiotic for Inflammation

At BlueBiology, we’re well aware of how many health issues are caused by chronic inflammation. From chronic fatigue to insomnia, weight issues, body aches, indigestion, anxiety, frequent infections, and even psychological issues like anxiety and depression, chronic inflammation can have a serious negative impact on your quality of life.

This is why we formulated BlueBiotics Ultimate Care with chronic inflammation in mind. There are just so many health issues cause by and related to chronic inflammation.

BlueBiotics contains 12 of the most efficient probiotic strains that have the widest range of health benefits. And the best part is that each and every one of these probiotic strains has been shown to reduce inflammation in scientific testing.

The probiotic strains that reduce inflammation in BlueBiotics Ultimate Care include:

  • Lactobacillus acidophilus complex
  • Saccharomyces boulardii complex
  • Bacillus coagulans complex
  • Lactobacillus bulgaricus complex
  • Bifidobacterium longum complex
  • Lactobacillus rhamnosus complex
  • Lactobacillus salivarius complex
  • Lactobacillus casei complex
  • Lactobacillus plantarum complex
  • Bifidobacterium lactis complex
  • Bifidobacterium breve complex

If you’re serious about living a healthier life free of chronic inflammation and all its unfortunate side effects, be sure to check out what we sincerely believe is the best probiotic for inflammation, BlueBiotics Ultimate Care.


If you have chronic inflammation, probiotics may be able to help reduce it, which could potentially get rid of any related side effects. Probiotics have many health benefits, but if you want probiotics specifically to reduce inflammation, look for probiotic products with these strains.

You can find many of these strains in our probiotic, BlueBiotics Ultimate Care.



  1. https://pubmed.ncbi.nlm.nih.gov/22001864/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020403/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947834/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908950/
  5. https://pubmed.ncbi.nlm.nih.gov/23957603/
  6. https://pubmed.ncbi.nlm.nih.gov/20661720/
  7. https://pubmed.ncbi.nlm.nih.gov/26418574/
  8. https://pubmed.ncbi.nlm.nih.gov/23037511/
  9. https://pubmed.ncbi.nlm.nih.gov/24480321/
  10. https://pubmed.ncbi.nlm.nih.gov/23555025/
  11. https://pubmed.ncbi.nlm.nih.gov/22211319/
  12. https://pubmed.ncbi.nlm.nih.gov/23638770/
  13. https://pubmed.ncbi.nlm.nih.gov/27698758/
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490534/
  15. https://pubmed.ncbi.nlm.nih.gov/25397892/
  16. https://pubmed.ncbi.nlm.nih.gov/22507188/
  17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761627/
  18. https://pubmed.ncbi.nlm.nih.gov/22526145/
  19. https://pubmed.ncbi.nlm.nih.gov/24991549/
  20. https://pubmed.ncbi.nlm.nih.gov/27032504/
  21. https://pubmed.ncbi.nlm.nih.gov/25727887/
  22. https://pubmed.ncbi.nlm.nih.gov/25536541/
  23. https://pubmed.ncbi.nlm.nih.gov/24108114/
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